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KMID : 0364820180540010046
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Korean Journal of Microbiology
2018 Volume.54 No. 1 p.46 ~ p.52
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Investigation of biodegradation pathway of dibenzofuran by Novosphingobium pentaromativorans US6-1 via transcriptomic and mass-spectrometric analysis
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Na Hye-Yun
Kwon Kae-Kyoung
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Abstract
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Biodegradation pathway of dibenzofuran (DBF) of Novosphingobium pentaromativorans US6-1, a high-molecular-weight polycyclic aromatic hydrocarbons degrading strain, was investigated via analysis of metabolic intermediates and transcriptome. As a result, 3(2H)-benzofuranone, a basic skeleton of the metabolic intermediates produced by lateral dioxygenation process, was detected as an intermediate. RNA-Seq analysis confirmed that most of the expressed genes upon exposure to DBF were related to the lateral degradation pathway. Based on these results, the biodegradation pathway of DBF by N. pentaromativorans US6-1 was proposed.
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KEYWORD
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Novosphingobium pentaromativorans US6-1, degradation pathway, dibenzofuran (DBF), metabolite, transcriptome
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